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Surprisingly, testing of Tyr78His and Arg106Pro variants in yeast, revealed no or moderate pathogenic effect, unlike the reported Pro107_Ala111del, Ala180Pro, and Glu233Val variants 2

It possesses renal protective properties by inhibiting the TLR4/NF-B signaling pathway, activating HO-1 to suppress myoglobin-induced inflammation and oxidative stress

10.3969/j.issn.1001-0408.2006.09.007 178 ZhangR

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